Fare Guide

Estimated lowest fares found within 7 days

Cheapest Airline American Airlines

The cheapest airline(s) flying from Knoxville to Chicago is American Airlines.

  • American Airlines American Airlines
  • United Airlines United Airlines
Cheapest Month November

Travel Period: December 2024 - November 2025

The cheapest month(s) to fly from Knoxville to Chicago is November.

  • Dec 2024
  • Jan 2025
  • Feb 2025
  • Mar 2025
  • Apr 2025
  • May 2025
  • Jun 2025
  • Jul 2025
  • Aug 2025
  • Sep 2025
  • Oct 2025
  • Nov 2025
Cheapest Day of the Week Saturday

The cheapest day(s) of the week to fly from Knoxville to Chicago is Saturday.

  • Sun Sunday
  • Mon Monday
  • Tue Tuesday
  • Wed Wednesday
  • Thu Thursday
  • Fri Friday
  • Sat Saturday

Flight Schedules

Last Updated: Sat, 2 Nov, 2024

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      • Availability
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      • 07:00 TYS
        08:01 ORD
        2Hrs, 01m Direct
      • TYSKnoxville Airport 07:00 - ORD 08:01 2h 01m Direct
      • TYSKnoxville Airport 07:00
      • ORDChicago O'Hare International Airport 08:01
      • 2h 01m
      • Direct
      • United Airlines (UA 1469)Boeing 737 700
      • United Airlines (UA 1469)
        • -
        • -
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      • Boeing 737 700
      • 07:00 TYS
        08:01 ORD
        2Hrs, 01m Direct
      • TYSKnoxville Airport 07:00 - ORD 08:01 2h 01m Direct
      • TYSKnoxville Airport 07:00
      • ORDChicago O'Hare International Airport 08:01
      • 2h 01m
      • Direct
      • United Airlines (UA 1469)Airbus
      • United Airlines (UA 1469)
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        • -
      • Airbus
      • 07:30 TYS
        08:32 ORD
        2Hrs, 02m Direct
      • TYSKnoxville Airport 07:30 - ORD 08:32 2h 02m Direct
      • TYSKnoxville Airport 07:30
      • ORDChicago O'Hare International Airport 08:32
      • 2h 02m
      • Direct
      • American Airlines (AA 5745)Er4 Embraer Rj145 Amazon
      • American Airlines (AA 5745)
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      • Er4 Embraer Rj145 Amazon
      • 10:55 TYS
        11:59 ORD
        2Hrs, 04m Direct
      • TYSKnoxville Airport 10:55 - ORD 11:59 2h 04m Direct
      • TYSKnoxville Airport 10:55
      • ORDChicago O'Hare International Airport 11:59
      • 2h 04m
      • Direct
      • United Airlines (UA 5300)Embraer 175
      • United Airlines (UA 5300)
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      • Embraer 175
      • 11:40 TYS
        12:42 ORD
        2Hrs, 02m Direct
      • TYSKnoxville Airport 11:40 - ORD 12:42 2h 02m Direct
      • TYSKnoxville Airport 11:40
      • ORDChicago O'Hare International Airport 12:42
      • 2h 02m
      • Direct
      • American Airlines (AA 5708)Er4 Embraer Rj145 Amazon
      • American Airlines (AA 5708)
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      • Er4 Embraer Rj145 Amazon
      • 11:42 TYS
        12:44 ORD
        2Hrs, 02m Direct
      • TYSKnoxville Airport 11:42 - ORD 12:44 2h 02m Direct
      • TYSKnoxville Airport 11:42
      • ORDChicago O'Hare International Airport 12:44
      • 2h 02m
      • Direct
      • American Airlines (AA 5708)Er4 Embraer Rj145 Amazon
      • American Airlines (AA 5708)
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        • -
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      • Er4 Embraer Rj145 Amazon
      • 13:13 TYS
        14:13 ORD
        2Hrs, 00m Direct
      • TYSKnoxville Airport 13:13 - ORD 14:13 2h Direct
      • TYSKnoxville Airport 13:13
      • ORDChicago O'Hare International Airport 14:13
      • 2h
      • Direct
      • American Airlines (AA 5708)Er4 Embraer Rj145 Amazon
      • American Airlines (AA 5708)
        • -
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      • Er4 Embraer Rj145 Amazon
      • 13:50 TYS
        14:24 MDW
        1Hrs, 34m Direct
      • TYSKnoxville Airport 13:50 - MDW 14:24 1h 34m Direct
      • TYSKnoxville Airport 13:50
      • MDWChicago Midway Airport 14:24
      • 1h 34m
      • Direct
      • Allegiant Air LLC (G4 1399)Airbus
      • Allegiant Air LLC (G4 1399)
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        • -
        • -
        • -
      • Airbus
      • 13:50 TYS
        14:24 MDW
        1Hrs, 34m Direct
      • TYSKnoxville Airport 13:50 - MDW 14:24 1h 34m Direct
      • TYSKnoxville Airport 13:50
      • MDWChicago Midway Airport 14:24
      • 1h 34m
      • Direct
      • Allegiant Air LLC (G4 3062)Airbus
      • Allegiant Air LLC (G4 3062)
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        • -
      • Airbus
      • 14:06 TYS
        15:12 ORD
        2Hrs, 06m Direct
      • TYSKnoxville Airport 14:06 - ORD 15:12 2h 06m Direct
      • TYSKnoxville Airport 14:06
      • ORDChicago O'Hare International Airport 15:12
      • 2h 06m
      • Direct
      • United Airlines (UA 3716)Embraer 175
      • United Airlines (UA 3716)
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        • S
      • Embraer 175
      • 17:43 TYS
        18:52 ORD
        2Hrs, 09m Direct
      • TYSKnoxville Airport 17:43 - ORD 18:52 2h 09m Direct
      • TYSKnoxville Airport 17:43
      • ORDChicago O'Hare International Airport 18:52
      • 2h 09m
      • Direct
      • United Airlines (UA 5330)Embraer 175
      • United Airlines (UA 5330)
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        • S
      • Embraer 175
      • 17:43 TYS
        18:55 ORD
        2Hrs, 12m Direct
      • TYSKnoxville Airport 17:43 - ORD 18:55 2h 12m Direct
      • TYSKnoxville Airport 17:43
      • ORDChicago O'Hare International Airport 18:55
      • 2h 12m
      • Direct
      • United Airlines (UA 5330)Crj Canadair Regional
      • United Airlines (UA 5330)
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        • -
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      • Crj Canadair Regional
      • 18:48 TYS
        19:50 ORD
        2Hrs, 02m Direct
      • TYSKnoxville Airport 18:48 - ORD 19:50 2h 02m Direct
      • TYSKnoxville Airport 18:48
      • ORDChicago O'Hare International Airport 19:50
      • 2h 02m
      • Direct
      • American Airlines (AA 5952)Er4 Embraer Rj145 Amazon
      • American Airlines (AA 5952)
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      • Er4 Embraer Rj145 Amazon
      • 18:54 TYS
        19:56 ORD
        2Hrs, 02m Direct
      • TYSKnoxville Airport 18:54 - ORD 19:56 2h 02m Direct
      • TYSKnoxville Airport 18:54
      • ORDChicago O'Hare International Airport 19:56
      • 2h 02m
      • Direct
      • American Airlines (AA 5952)Er4 Embraer Rj145 Amazon
      • American Airlines (AA 5952)
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        • -
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      • Er4 Embraer Rj145 Amazon
      • 19:25 TYS
        23:20 ORD
        4Hrs, 55m 1 Stop (IAD)
      • TYSKnoxville Airport 19:25 - ORD 23:20 4h 55m 1 Stop (IAD) Washington
      • TYSKnoxville Airport 19:25
        IADWashington Dulles International Airport 22:16
      • IADWashington Dulles International Airport 21:15
        ORDChicago O'Hare International Airport 23:20
      • 4h 55m (1h 01m)
      • 1 Stop IAD · Washington 1h 01m
      • United Airlines (UA 4324)Embraer
        United Airlines (UA 1738)Airbus
      • United Airlines (UA 4324)
        • -
        • -
        • -
        • -
        • -
        • -
        • S
      • 19:25 TYS
        23:20 ORD
        4Hrs, 55m 1 Stop (IAD)
      • TYSKnoxville Airport 19:25 - ORD 23:20 4h 55m 1 Stop (IAD) Washington
      • TYSKnoxville Airport 19:25
        IADWashington Dulles International Airport 22:16
      • IADWashington Dulles International Airport 21:15
        ORDChicago O'Hare International Airport 23:20
      • 4h 55m (1h 01m)
      • 1 Stop IAD · Washington 1h 01m
      • United Airlines (UA 4324)Embraer
        United Airlines (UA 1738)Boeing 737 800
      • United Airlines (UA 4324)
        • M
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        • -
      • 19:25 TYS
        23:20 ORD
        4Hrs, 55m 1 Stop (IAD)
      • TYSKnoxville Airport 19:25 - ORD 23:20 4h 55m 1 Stop (IAD) Washington
      • TYSKnoxville Airport 19:25
        IADWashington Dulles International Airport 22:16
      • IADWashington Dulles International Airport 21:15
        ORDChicago O'Hare International Airport 23:20
      • 4h 55m (1h 01m)
      • 1 Stop IAD · Washington 1h 01m
      • United Airlines (UA 4324)Embraer
        United Airlines (UA 1738)Boeing 737 900
      • United Airlines (UA 4324)
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        • -
        • -
        • F
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        • -
      • 19:25 TYS
        23:20 ORD
        4Hrs, 55m 1 Stop (IAD)
      • TYSKnoxville Airport 19:25 - ORD 23:20 4h 55m 1 Stop (IAD) Washington
      • TYSKnoxville Airport 19:25
        IADWashington Dulles International Airport 22:16
      • IADWashington Dulles International Airport 21:15
        ORDChicago O'Hare International Airport 23:20
      • 4h 55m (1h 01m)
      • 1 Stop IAD · Washington 1h 01m
      • United Airlines (UA 4324)Embraer
        United Airlines (UA 1738)Boeing 737 700
      • United Airlines (UA 4324)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 20:08 TYS
        00:16 ORD
        5Hrs, 08m 1 Stop (CLT)
      • TYSKnoxville Airport 20:08 - ORD 00:16 5h 08m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 20:08
        CLTCharlotte Airport 22:56
      • CLTCharlotte Airport 21:34
        ORDChicago O'Hare International Airport 00:16
      • 5h 08m (1h 22m)
      • 1 Stop CLT · Charlotte 1h 22m
      • American Airlines (AA 5173)Canadair Regional
        American Airlines (AA 1180)Boeing 737 800
      • American Airlines (AA 5173)
        • M
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      • 05:00 TYS
        08:42 ORD
        4Hrs, 42m 1 Stop (CLT)
      • TYSKnoxville Airport 05:00 - ORD 08:42 4h 42m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 05:00
        CLTCharlotte Airport 07:34
      • CLTCharlotte Airport 06:23
        ORDChicago O'Hare International Airport 08:42
      • 4h 42m (1h 11m)
      • 1 Stop CLT · Charlotte 1h 11m
      • American Airlines (AA 5435)Canadair Regional
        American Airlines (AA 2843)Airbus
      • American Airlines (AA 5435)
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        • S
      • 05:45 TYS
        09:49 ORD
        5Hrs, 04m 1 Stop (IAD)
      • TYSKnoxville Airport 05:45 - ORD 09:49 5h 04m 1 Stop (IAD) Washington
      • TYSKnoxville Airport 05:45
        IADWashington Dulles International Airport 08:35
      • IADWashington Dulles International Airport 07:33
        ORDChicago O'Hare International Airport 09:49
      • 5h 04m (1h 02m)
      • 1 Stop IAD · Washington 1h 02m
      • United Airlines (UA 4311)Embraer
        United Airlines (UA 672)Boeing 737 800
      • United Airlines (UA 4311)
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      • 05:45 TYS
        09:29 ORD
        4Hrs, 44m 1 Stop (IAD)
      • TYSKnoxville Airport 05:45 - ORD 09:29 4h 44m 1 Stop (IAD) Washington
      • TYSKnoxville Airport 05:45
        IADWashington Dulles International Airport 08:15
      • IADWashington Dulles International Airport 07:33
        ORDChicago O'Hare International Airport 09:29
      • 4h 44m (42m)
      • 1 Stop IAD · Washington 42m
      • United Airlines (UA 4311)Embraer
        United Airlines (UA 672)Boeing 737 800
      • United Airlines (UA 4311)
        • -
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        • -
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        • -
      • 07:03 TYS
        10:50 ORD
        4Hrs, 47m 1 Stop (CLT)
      • TYSKnoxville Airport 07:03 - ORD 10:50 4h 47m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 07:03
        CLTCharlotte Airport 09:33
      • CLTCharlotte Airport 08:30
        ORDChicago O'Hare International Airport 10:50
      • 4h 47m (1h 03m)
      • 1 Stop CLT · Charlotte 1h 03m
      • American Airlines (AA 5087)Crj 700 Canadair Regional
        American Airlines (AA 1668)Boeing 737 Max 8 Passenger
      • American Airlines (AA 5087)
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      • 07:03 TYS
        10:48 ORD
        4Hrs, 45m 1 Stop (CLT)
      • TYSKnoxville Airport 07:03 - ORD 10:48 4h 45m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 07:03
        CLTCharlotte Airport 09:33
      • CLTCharlotte Airport 08:30
        ORDChicago O'Hare International Airport 10:48
      • 4h 45m (1h 03m)
      • 1 Stop CLT · Charlotte 1h 03m
      • American Airlines (AA 5087)Crj 700 Canadair Regional
        American Airlines (AA 1668)Boeing 737 Max 8 Passenger
      • American Airlines (AA 5087)
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        • S
      • 07:50 TYS
        12:25 ORD
        5Hrs, 35m 1 Stop (PHL)
      • TYSKnoxville Airport 07:50 - ORD 12:25 5h 35m 1 Stop (PHL) Philadelphia
      • TYSKnoxville Airport 07:50
        PHLPhiladelphia International Airport 10:46
      • PHLPhiladelphia International Airport 09:44
        ORDChicago O'Hare International Airport 12:25
      • 5h 35m (1h 02m)
      • 1 Stop PHL · Philadelphia 1h 02m
      • American Airlines (AA 5620)Canadair Regional
        American Airlines (AA 1920)Boeing 737 800
      • American Airlines (AA 5620)
        • M
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        • -
        • -
        • -
      • 07:50 TYS
        12:24 ORD
        5Hrs, 34m 1 Stop (PHL)
      • TYSKnoxville Airport 07:50 - ORD 12:24 5h 34m 1 Stop (PHL) Philadelphia
      • TYSKnoxville Airport 07:50
        PHLPhiladelphia International Airport 10:46
      • PHLPhiladelphia International Airport 09:44
        ORDChicago O'Hare International Airport 12:24
      • 5h 34m (1h 02m)
      • 1 Stop PHL · Philadelphia 1h 02m
      • American Airlines (AA 5620)Canadair Regional
        American Airlines (AA 1920)Boeing 737 800
      • American Airlines (AA 5620)
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        • -
      • 07:50 TYS
        12:25 ORD
        5Hrs, 35m 1 Stop (PHL)
      • TYSKnoxville Airport 07:50 - ORD 12:25 5h 35m 1 Stop (PHL) Philadelphia
      • TYSKnoxville Airport 07:50
        PHLPhiladelphia International Airport 10:50
      • PHLPhiladelphia International Airport 09:44
        ORDChicago O'Hare International Airport 12:25
      • 5h 35m (1h 06m)
      • 1 Stop PHL · Philadelphia 1h 06m
      • American Airlines (AA 5620)Canadair Regional
        American Airlines (AA 1920)Boeing 737 800
      • American Airlines (AA 5620)
        • -
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        • -
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        • S
      • 09:09 TYS
        12:15 ORD
        4Hrs, 06m 1 Stop (CLT)
      • TYSKnoxville Airport 09:09 - ORD 12:15 4h 06m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 09:09
        CLTCharlotte Airport 11:10
      • CLTCharlotte Airport 10:25
        ORDChicago O'Hare International Airport 12:15
      • 4h 06m (45m)
      • 1 Stop CLT · Charlotte 45m
      • American Airlines (AA 5417)Canadair Regional
        American Airlines (AA 2279)Boeing 737 800
      • American Airlines (AA 5417)
        • M
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      • 09:09 TYS
        13:10 ORD
        5Hrs, 01m 1 Stop (CLT)
      • TYSKnoxville Airport 09:09 - ORD 13:10 5h 01m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 09:09
        CLTCharlotte Airport 11:40
      • CLTCharlotte Airport 10:25
        ORDChicago O'Hare International Airport 13:10
      • 5h 01m (1h 15m)
      • 1 Stop CLT · Charlotte 1h 15m
      • American Airlines (AA 5417)Canadair Regional
        American Airlines (AA 2279)Boeing 737 800
      • American Airlines (AA 5417)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 09:09 TYS
        12:24 ORD
        4Hrs, 15m 1 Stop (CLT)
      • TYSKnoxville Airport 09:09 - ORD 12:24 4h 15m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 09:09
        CLTCharlotte Airport 11:13
      • CLTCharlotte Airport 10:25
        ORDChicago O'Hare International Airport 12:24
      • 4h 15m (48m)
      • 1 Stop CLT · Charlotte 48m
      • American Airlines (AA 5417)Canadair Regional
        American Airlines (AA 2279)Boeing 737 800
      • American Airlines (AA 5417)
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        • -
        • -
      • 09:50 TYS
        14:19 ORD
        5Hrs, 29m 1 Stop (IAD)
      • TYSKnoxville Airport 09:50 - ORD 14:19 5h 29m 1 Stop (IAD) Washington
      • TYSKnoxville Airport 09:50
        IADWashington Dulles International Airport 13:05
      • IADWashington Dulles International Airport 11:33
        ORDChicago O'Hare International Airport 14:19
      • 5h 29m (1h 32m)
      • 1 Stop IAD · Washington 1h 32m
      • United Airlines (UA 4325)Embraer
        United Airlines (UA 673)Boeing 737 800
      • United Airlines (UA 4325)
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        • T
        • F
        • -
        • S
      • 09:50 TYS
        14:19 ORD
        5Hrs, 29m 1 Stop (IAD)
      • TYSKnoxville Airport 09:50 - ORD 14:19 5h 29m 1 Stop (IAD) Washington
      • TYSKnoxville Airport 09:50
        IADWashington Dulles International Airport 13:05
      • IADWashington Dulles International Airport 11:33
        ORDChicago O'Hare International Airport 14:19
      • 5h 29m (1h 32m)
      • 1 Stop IAD · Washington 1h 32m
      • United Airlines (UA 4325)Embraer
        United Airlines (UA 673)Boeing 737 Max 8 Passenger
      • United Airlines (UA 4325)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 10:46 TYS
        14:17 ORD
        4Hrs, 31m 1 Stop (CLT)
      • TYSKnoxville Airport 10:46 - ORD 14:17 4h 31m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 10:46
        CLTCharlotte Airport 13:07
      • CLTCharlotte Airport 12:02
        ORDChicago O'Hare International Airport 14:17
      • 4h 31m (1h 05m)
      • 1 Stop CLT · Charlotte 1h 05m
      • American Airlines (AA 5580)Canadair Regional
        American Airlines (AA 1052)Boeing 737 800
      • American Airlines (AA 5580)
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        • -
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        • -
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        • -
        • -
      • 10:46 TYS
        14:10 ORD
        4Hrs, 24m 1 Stop (CLT)
      • TYSKnoxville Airport 10:46 - ORD 14:10 4h 24m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 10:46
        CLTCharlotte Airport 13:00
      • CLTCharlotte Airport 12:02
        ORDChicago O'Hare International Airport 14:10
      • 4h 24m (58m)
      • 1 Stop CLT · Charlotte 58m
      • American Airlines (AA 5580)Canadair Regional
        American Airlines (AA 1052)Boeing 737 800
      • American Airlines (AA 5580)
        • -
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        • -
        • -
        • -
        • -
        • -
      • 10:46 TYS
        14:15 ORD
        4Hrs, 29m 1 Stop (CLT)
      • TYSKnoxville Airport 10:46 - ORD 14:15 4h 29m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 10:46
        CLTCharlotte Airport 13:07
      • CLTCharlotte Airport 12:02
        ORDChicago O'Hare International Airport 14:15
      • 4h 29m (1h 05m)
      • 1 Stop CLT · Charlotte 1h 05m
      • American Airlines (AA 5580)Canadair Regional
        American Airlines (AA 1052)Boeing 737 800
      • American Airlines (AA 5580)
        • -
        • -
        • -
        • -
        • -
        • S
        • -
      • 10:46 TYS
        14:24 ORD
        4Hrs, 38m 1 Stop (CLT)
      • TYSKnoxville Airport 10:46 - ORD 14:24 4h 38m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 10:46
        CLTCharlotte Airport 13:16
      • CLTCharlotte Airport 12:02
        ORDChicago O'Hare International Airport 14:24
      • 4h 38m (1h 14m)
      • 1 Stop CLT · Charlotte 1h 14m
      • American Airlines (AA 5580)Canadair Regional
        American Airlines (AA 1052)Boeing 737 800
      • American Airlines (AA 5580)
        • M
        • -
        • -
        • T
        • F
        • -
        • S
      • 11:00 TYS
        15:14 ORD
        5Hrs, 14m 1 Stop (PHL)
      • TYSKnoxville Airport 11:00 - ORD 15:14 5h 14m 1 Stop (PHL) Philadelphia
      • TYSKnoxville Airport 11:00
        PHLPhiladelphia International Airport 13:45
      • PHLPhiladelphia International Airport 12:47
        ORDChicago O'Hare International Airport 15:14
      • 5h 14m (58m)
      • 1 Stop PHL · Philadelphia 58m
      • American Airlines (AA 5908)Er4 Embraer Rj145 Amazon
        American Airlines (AA 470)Airbus
      • American Airlines (AA 5908)
        • -
        • -
        • -
        • T
        • F
        • S
        • S
      • 13:27 TYS
        17:43 ORD
        5Hrs, 16m 1 Stop (CLT)
      • TYSKnoxville Airport 13:27 - ORD 17:43 5h 16m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 13:27
        CLTCharlotte Airport 16:34
      • CLTCharlotte Airport 14:44
        ORDChicago O'Hare International Airport 17:43
      • 5h 16m (1h 50m)
      • 1 Stop CLT · Charlotte 1h 50m
      • American Airlines (AA 5113)Canadair Regional
        American Airlines (AA 1763)Boeing 737 800
      • American Airlines (AA 5113)
        • M
        • -
        • -
        • T
        • F
        • S
        • S
      • 13:27 TYS
        17:56 ORD
        5Hrs, 29m 1 Stop (CLT)
      • TYSKnoxville Airport 13:27 - ORD 17:56 5h 29m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 13:27
        CLTCharlotte Airport 16:42
      • CLTCharlotte Airport 14:44
        ORDChicago O'Hare International Airport 17:56
      • 5h 29m (1h 58m)
      • 1 Stop CLT · Charlotte 1h 58m
      • American Airlines (AA 5113)Canadair Regional
        American Airlines (AA 1763)Boeing 737 800
      • American Airlines (AA 5113)
        • -
        • -
        • W
        • -
        • -
        • -
        • -
      • 14:35 TYS
        18:35 ORD
        5Hrs, 00m 1 Stop (IAD)
      • TYSKnoxville Airport 14:35 - ORD 18:35 5h 1 Stop (IAD) Washington
      • TYSKnoxville Airport 14:35
        IADWashington Dulles International Airport 17:21
      • IADWashington Dulles International Airport 16:15
        ORDChicago O'Hare International Airport 18:35
      • 5h (1h 06m)
      • 1 Stop IAD · Washington 1h 06m
      • United Airlines (UA 4848)Embraer
        United Airlines (UA 2497)Airbus
      • United Airlines (UA 4848)
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      • 14:35 TYS
        18:35 ORD
        5Hrs, 00m 1 Stop (IAD)
      • TYSKnoxville Airport 14:35 - ORD 18:35 5h 1 Stop (IAD) Washington
      • TYSKnoxville Airport 14:35
        IADWashington Dulles International Airport 17:21
      • IADWashington Dulles International Airport 16:15
        ORDChicago O'Hare International Airport 18:35
      • 5h (1h 06m)
      • 1 Stop IAD · Washington 1h 06m
      • United Airlines (UA 4848)Embraer
        United Airlines (UA 2497)Boeing 737 800
      • United Airlines (UA 4848)
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      • 14:35 TYS
        18:35 ORD
        5Hrs, 00m 1 Stop (IAD)
      • TYSKnoxville Airport 14:35 - ORD 18:35 5h 1 Stop (IAD) Washington
      • TYSKnoxville Airport 14:35
        IADWashington Dulles International Airport 17:21
      • IADWashington Dulles International Airport 16:15
        ORDChicago O'Hare International Airport 18:35
      • 5h (1h 06m)
      • 1 Stop IAD · Washington 1h 06m
      • United Airlines (UA 4848)Embraer
        United Airlines (UA 2497)Airbus
      • United Airlines (UA 4848)
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      • 14:56 TYS
        19:24 ORD
        5Hrs, 28m 1 Stop (CLT)
      • TYSKnoxville Airport 14:56 - ORD 19:24 5h 28m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 14:56
        CLTCharlotte Airport 18:15
      • CLTCharlotte Airport 16:13
        ORDChicago O'Hare International Airport 19:24
      • 5h 28m (2h 02m)
      • 1 Stop CLT · Charlotte 2h 02m
      • American Airlines (AA 5197)Crj 700 Canadair Regional
        American Airlines (AA 2488)Airbus
      • American Airlines (AA 5197)
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      • 14:56 TYS
        19:11 ORD
        5Hrs, 15m 1 Stop (CLT)
      • TYSKnoxville Airport 14:56 - ORD 19:11 5h 15m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 14:56
        CLTCharlotte Airport 18:01
      • CLTCharlotte Airport 16:13
        ORDChicago O'Hare International Airport 19:11
      • 5h 15m (1h 48m)
      • 1 Stop CLT · Charlotte 1h 48m
      • American Airlines (AA 5197)Crj 700 Canadair Regional
        American Airlines (AA 2488)Airbus
      • American Airlines (AA 5197)
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      • 14:56 TYS
        19:08 ORD
        5Hrs, 12m 1 Stop (CLT)
      • TYSKnoxville Airport 14:56 - ORD 19:08 5h 12m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 14:56
        CLTCharlotte Airport 18:01
      • CLTCharlotte Airport 16:13
        ORDChicago O'Hare International Airport 19:08
      • 5h 12m (1h 48m)
      • 1 Stop CLT · Charlotte 1h 48m
      • American Airlines (AA 5197)Crj 700 Canadair Regional
        American Airlines (AA 2488)Airbus
      • American Airlines (AA 5197)
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        • S
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      • 14:56 TYS
        19:22 ORD
        5Hrs, 26m 1 Stop (CLT)
      • TYSKnoxville Airport 14:56 - ORD 19:22 5h 26m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 14:56
        CLTCharlotte Airport 18:15
      • CLTCharlotte Airport 16:13
        ORDChicago O'Hare International Airport 19:22
      • 5h 26m (2h 02m)
      • 1 Stop CLT · Charlotte 2h 02m
      • American Airlines (AA 5197)Crj 700 Canadair Regional
        American Airlines (AA 2488)Airbus
      • American Airlines (AA 5197)
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      • 16:12 TYS
        19:24 ORD
        4Hrs, 12m 1 Stop (CLT)
      • TYSKnoxville Airport 16:12 - ORD 19:24 4h 12m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 16:12
        CLTCharlotte Airport 18:15
      • CLTCharlotte Airport 17:27
        ORDChicago O'Hare International Airport 19:24
      • 4h 12m (48m)
      • 1 Stop CLT · Charlotte 48m
      • American Airlines (AA 5853)Er4 Embraer Rj145 Amazon
        American Airlines (AA 2488)Airbus
      • American Airlines (AA 5853)
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      • 16:12 TYS
        19:22 ORD
        4Hrs, 10m 1 Stop (CLT)
      • TYSKnoxville Airport 16:12 - ORD 19:22 4h 10m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 16:12
        CLTCharlotte Airport 18:15
      • CLTCharlotte Airport 17:27
        ORDChicago O'Hare International Airport 19:22
      • 4h 10m (48m)
      • 1 Stop CLT · Charlotte 48m
      • American Airlines (AA 5853)Er4 Embraer Rj145 Amazon
        American Airlines (AA 2488)Airbus
      • American Airlines (AA 5853)
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      • 18:04 TYS
        22:29 ORD
        5Hrs, 25m 1 Stop (CLT)
      • TYSKnoxville Airport 18:04 - ORD 22:29 5h 25m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 18:04
        CLTCharlotte Airport 21:15
      • CLTCharlotte Airport 19:21
        ORDChicago O'Hare International Airport 22:29
      • 5h 25m (1h 54m)
      • 1 Stop CLT · Charlotte 1h 54m
      • American Airlines (AA 5682)Er4 Embraer Rj145 Amazon
        American Airlines (AA 815)Airbus
      • American Airlines (AA 5682)
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        • -
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        • S
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      • 18:04 TYS
        21:38 ORD
        4Hrs, 34m 1 Stop (CLT)
      • TYSKnoxville Airport 18:04 - ORD 21:38 4h 34m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 18:04
        CLTCharlotte Airport 20:30
      • CLTCharlotte Airport 19:21
        ORDChicago O'Hare International Airport 21:38
      • 4h 34m (1h 09m)
      • 1 Stop CLT · Charlotte 1h 09m
      • American Airlines (AA 5682)Er4 Embraer Rj145 Amazon
        American Airlines (AA 815)Airbus
      • American Airlines (AA 5682)
        • M
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      • 18:04 TYS
        21:39 ORD
        4Hrs, 35m 1 Stop (CLT)
      • TYSKnoxville Airport 18:04 - ORD 21:39 4h 35m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 18:04
        CLTCharlotte Airport 20:30
      • CLTCharlotte Airport 19:21
        ORDChicago O'Hare International Airport 21:39
      • 4h 35m (1h 09m)
      • 1 Stop CLT · Charlotte 1h 09m
      • American Airlines (AA 5682)Er4 Embraer Rj145 Amazon
        American Airlines (AA 815)Airbus
      • American Airlines (AA 5682)
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      • 18:21 TYS
        22:53 ORD
        5Hrs, 32m 1 Stop (PHL)
      • TYSKnoxville Airport 18:21 - ORD 22:53 5h 32m 1 Stop (PHL) Philadelphia
      • TYSKnoxville Airport 18:21
        PHLPhiladelphia International Airport 21:20
      • PHLPhiladelphia International Airport 20:08
        ORDChicago O'Hare International Airport 22:53
      • 5h 32m (1h 12m)
      • 1 Stop PHL · Philadelphia 1h 12m
      • American Airlines (AA 5766)Er4 Embraer Rj145 Amazon
        American Airlines (AA 2554)Boeing 737 800
      • American Airlines (AA 5766)
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      • 18:23 TYS
        21:39 ORD
        4Hrs, 16m 1 Stop (CLT)
      • TYSKnoxville Airport 18:23 - ORD 21:39 4h 16m 1 Stop (CLT) Charlotte
      • TYSKnoxville Airport 18:23
        CLTCharlotte Airport 20:30
      • CLTCharlotte Airport 19:40
        ORDChicago O'Hare International Airport 21:39
      • 4h 16m (50m)
      • 1 Stop CLT · Charlotte 50m
      • American Airlines (AA 5682)Er4 Embraer Rj145 Amazon
        American Airlines (AA 815)Airbus
      • American Airlines (AA 5682)
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      • 18:33 TYS
        22:53 ORD
        5Hrs, 20m 1 Stop (PHL)
      • TYSKnoxville Airport 18:33 - ORD 22:53 5h 20m 1 Stop (PHL) Philadelphia
      • TYSKnoxville Airport 18:33
        PHLPhiladelphia International Airport 21:20
      • PHLPhiladelphia International Airport 20:20
        ORDChicago O'Hare International Airport 22:53
      • 5h 20m (1h)
      • 1 Stop PHL · Philadelphia 1h
      • American Airlines (AA 5766)Er4 Embraer Rj145 Amazon
        American Airlines (AA 2554)Boeing 737 800
      • American Airlines (AA 5766)
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      What’s the fastest flight time from Knoxville to Chicago?

      The fastest flight time for direct flights from Knoxville to Chicago is 1 hour 34 minutes. Check latest flight schedules & prices on Wego.

      How far is Chicago from Knoxville?

      The flight distance between Knoxville and Chicago is 732km. Check all available flights on Wego.

      When is the earliest and latest flight of the day?

      The earliest flight of the day departs at 05:00. The last flight of the day departs at 19:25. See the full list of flight times on Wego.

      How many airlines offer direct flights from Knoxville to Chicago?

      There are 3 airlines that offer direct flights from Knoxville to Chicago. Find out the list of airlines on Wego.

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