Fare Guide

Estimated lowest fares found within 7 days

Cheapest Airline JetSmart

The cheapest airline(s) flying from Santo Domingo to Santiago is JetSmart.

  • JetSmart JetSmart
  • Copa Airlines Copa Airlines
  • Avianca Avianca
  • Arajet Arajet
  • American Airlines American Airlines
  • LATAM Airlines Group SA LATAM Airlines Group SA
Cheapest Month February

Travel Period: December 2024 - November 2025

The cheapest month(s) to fly from Santo Domingo to Santiago is February.

  • Dec 2024
  • Jan 2025
  • Feb 2025
  • Mar 2025
  • Apr 2025
  • May 2025
  • Jun 2025
  • Jul 2025
  • Aug 2025
  • Sep 2025
  • Oct 2025
  • Nov 2025
Cheapest Day of the Week Saturday

The cheapest day(s) of the week to fly from Santo Domingo to Santiago is Saturday.

  • Sun Sunday
  • Mon Monday
  • Tue Tuesday
  • Wed Wednesday
  • Thu Thursday
  • Fri Friday
  • Sat Saturday

Flight Schedules

Last Updated: Sat, 2 Nov, 2024

  • Time Earliest
    • Earliest
    • Latest
  • Depart Earliest
    • Earliest
    • Latest
  • Arrive
    • Earliest
    • Latest
  • Duration
    • Shortest
    • Longest
  • Stopover
    All
  • Airline Filter by Airline
    View All Airline
  • Availability
    • M
    • T
    • W
    • T
    • F
    • S
    • S
  • 06:16 SDQ
    20:12 SCL
    12Hrs, 56m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 06:16 - SCL 20:12 12h 56m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 06:16
    PTYPanama City Tocumen International Airport 11:47
  • PTYPanama City Tocumen International Airport 08:00
    SCLSantiago Arturo Merino Benitez Airport 20:12
  • 12h 56m (3h 47m)
  • 1 Stop PTY · Panama City 3h 47m
  • Copa Airlines (CM 108)Boeing 737 700
    Copa Airlines (CM 395)Boeing 737 Max 9 Passenger
  • Copa Airlines (CM 108)
    • -
    • T
    • W
    • T
    • F
    • S
    • S
  • 08:53 SDQ
    23:47 SCL
    13Hrs, 54m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 08:53 - SCL 23:47 13h 54m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 08:53
    PTYPanama City Tocumen International Airport 15:14
  • PTYPanama City Tocumen International Airport 10:30
    SCLSantiago Arturo Merino Benitez Airport 23:47
  • 13h 54m (4h 44m)
  • 1 Stop PTY · Panama City 4h 44m
  • Copa Airlines (CM 267)Boeing 737 800
    Copa Airlines (CM 497)Boeing 737 800
  • Copa Airlines (CM 267)
    • M
    • T
    • W
    • T
    • -
    • S
    • S
  • 08:53 SDQ
    00:05 SCL
    14Hrs, 12m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 08:53 - SCL 00:05 14h 12m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 08:53
    PTYPanama City Tocumen International Airport 15:32
  • PTYPanama City Tocumen International Airport 10:30
    SCLSantiago Arturo Merino Benitez Airport 00:05
  • 14h 12m (5h 02m)
  • 1 Stop PTY · Panama City 5h 02m
  • Copa Airlines (CM 267)Boeing 737 800
    Copa Airlines (CM 171)Boeing 737 800
  • Copa Airlines (CM 267)
    • -
    • -
    • -
    • -
    • F
    • -
    • -
  • 08:53 SDQ
    20:12 SCL
    10Hrs, 19m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 08:53 - SCL 20:12 10h 19m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 08:53
    PTYPanama City Tocumen International Airport 11:47
  • PTYPanama City Tocumen International Airport 10:30
    SCLSantiago Arturo Merino Benitez Airport 20:12
  • 10h 19m (1h 17m)
  • 1 Stop PTY · Panama City 1h 17m
  • Copa Airlines (CM 267)Boeing 737 800
    Copa Airlines (CM 395)Boeing 737 Max 9 Passenger
  • Copa Airlines (CM 267)
    • M
    • T
    • W
    • T
    • F
    • S
    • S
  • 11:50 SDQ
    23:40 SCL
    10Hrs, 50m 1 Stop (BOG)
  • SDQSanto Domingo Las Americas Airport 11:50 - SCL 23:40 10h 50m 1 Stop (BOG)
  • SDQSanto Domingo Las Americas Airport 11:50
    BOGBogota Airport 15:30
  • BOGBogota Airport 13:25
    SCLSantiago Arturo Merino Benitez Airport 23:40
  • 10h 50m (2h 05m)
  • 1 Stop BOG · 2h 05m
  • Avianca (AV 209)Airbus A320 Neo
    Avianca (AV 241)Airbus A320 Neo
  • Avianca (AV 209)
    • M
    • T
    • -
    • -
    • -
    • S
    • -
  • 11:50 SDQ
    23:40 SCL
    10Hrs, 50m 1 Stop (BOG)
  • SDQSanto Domingo Las Americas Airport 11:50 - SCL 23:40 10h 50m 1 Stop (BOG)
  • SDQSanto Domingo Las Americas Airport 11:50
    BOGBogota Airport 15:30
  • BOGBogota Airport 13:25
    SCLSantiago Arturo Merino Benitez Airport 23:40
  • 10h 50m (2h 05m)
  • 1 Stop BOG · 2h 05m
  • Avianca (AV 209)Airbus
    Avianca (AV 241)Airbus A320 Neo
  • Avianca (AV 209)
    • -
    • -
    • -
    • T
    • -
    • -
    • -
  • 11:53 SDQ
    03:38 SCL
    14Hrs, 45m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 11:53 - SCL 03:38 14h 45m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 11:53
    PTYPanama City Tocumen International Airport 19:05
  • PTYPanama City Tocumen International Airport 13:30
    SCLSantiago Arturo Merino Benitez Airport 03:38
  • 14h 45m (5h 35m)
  • 1 Stop PTY · Panama City 5h 35m
  • Copa Airlines (CM 129)Boeing 737 Max 9 Passenger
    Copa Airlines (CM 474)Boeing 737 800
  • Copa Airlines (CM 129)
    • -
    • -
    • -
    • -
    • F
    • -
    • -
  • 11:53 SDQ
    00:05 SCL
    11Hrs, 12m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 11:53 - SCL 00:05 11h 12m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 11:53
    PTYPanama City Tocumen International Airport 15:32
  • PTYPanama City Tocumen International Airport 13:30
    SCLSantiago Arturo Merino Benitez Airport 00:05
  • 11h 12m (2h 02m)
  • 1 Stop PTY · Panama City 2h 02m
  • Copa Airlines (CM 129)Boeing 737 800
    Copa Airlines (CM 171)Boeing 737 800
  • Copa Airlines (CM 129)
    • M
    • -
    • W
    • T
    • -
    • S
    • -
  • 11:53 SDQ
    00:05 SCL
    11Hrs, 12m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 11:53 - SCL 00:05 11h 12m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 11:53
    PTYPanama City Tocumen International Airport 15:32
  • PTYPanama City Tocumen International Airport 13:30
    SCLSantiago Arturo Merino Benitez Airport 00:05
  • 11h 12m (2h 02m)
  • 1 Stop PTY · Panama City 2h 02m
  • Copa Airlines (CM 129)Boeing 737 Max 9 Passenger
    Copa Airlines (CM 171)Boeing 737 800
  • Copa Airlines (CM 129)
    • -
    • T
    • -
    • -
    • F
    • -
    • S
  • 11:53 SDQ
    23:47 SCL
    10Hrs, 54m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 11:53 - SCL 23:47 10h 54m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 11:53
    PTYPanama City Tocumen International Airport 15:14
  • PTYPanama City Tocumen International Airport 13:30
    SCLSantiago Arturo Merino Benitez Airport 23:47
  • 10h 54m (1h 44m)
  • 1 Stop PTY · Panama City 1h 44m
  • Copa Airlines (CM 129)Boeing 737 Max 9 Passenger
    Copa Airlines (CM 497)Boeing 737 800
  • Copa Airlines (CM 129)
    • -
    • T
    • -
    • -
    • -
    • -
    • S
  • 11:53 SDQ
    23:47 SCL
    10Hrs, 54m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 11:53 - SCL 23:47 10h 54m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 11:53
    PTYPanama City Tocumen International Airport 15:14
  • PTYPanama City Tocumen International Airport 13:30
    SCLSantiago Arturo Merino Benitez Airport 23:47
  • 10h 54m (1h 44m)
  • 1 Stop PTY · Panama City 1h 44m
  • Copa Airlines (CM 129)Boeing 737 800
    Copa Airlines (CM 497)Boeing 737 800
  • Copa Airlines (CM 129)
    • M
    • -
    • W
    • T
    • -
    • S
    • -
  • 14:40 SDQ
    05:54 SCL
    14Hrs, 14m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 14:40 - SCL 05:54 14h 14m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 14:40
    PTYPanama City Tocumen International Airport 21:31
  • PTYPanama City Tocumen International Airport 16:17
    SCLSantiago Arturo Merino Benitez Airport 05:54
  • 14h 14m (5h 14m)
  • 1 Stop PTY · Panama City 5h 14m
  • Copa Airlines (CM 299)Boeing 737 700
    Copa Airlines (CM 277)Boeing 737 Max 9 Passenger
  • Copa Airlines (CM 299)
    • -
    • -
    • -
    • T
    • -
    • -
    • S
  • 14:40 SDQ
    03:24 SCL
    11Hrs, 44m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 14:40 - SCL 03:24 11h 44m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 14:40
    PTYPanama City Tocumen International Airport 18:51
  • PTYPanama City Tocumen International Airport 16:17
    SCLSantiago Arturo Merino Benitez Airport 03:24
  • 11h 44m (2h 34m)
  • 1 Stop PTY · Panama City 2h 34m
  • Copa Airlines (CM 299)Boeing 737 800
    Copa Airlines (CM 172)Boeing 737 800
  • Copa Airlines (CM 299)
    • -
    • -
    • -
    • -
    • -
    • S
    • -
  • 14:40 SDQ
    03:38 SCL
    11Hrs, 58m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 14:40 - SCL 03:38 11h 58m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 14:40
    PTYPanama City Tocumen International Airport 19:05
  • PTYPanama City Tocumen International Airport 16:17
    SCLSantiago Arturo Merino Benitez Airport 03:38
  • 11h 58m (2h 48m)
  • 1 Stop PTY · Panama City 2h 48m
  • Copa Airlines (CM 299)Boeing 737 800
    Copa Airlines (CM 474)Boeing 737 800
  • Copa Airlines (CM 299)
    • M
    • T
    • W
    • -
    • F
    • -
    • -
  • 14:40 SDQ
    03:38 SCL
    11Hrs, 58m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 14:40 - SCL 03:38 11h 58m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 14:40
    PTYPanama City Tocumen International Airport 19:05
  • PTYPanama City Tocumen International Airport 16:17
    SCLSantiago Arturo Merino Benitez Airport 03:38
  • 11h 58m (2h 48m)
  • 1 Stop PTY · Panama City 2h 48m
  • Copa Airlines (CM 299)Boeing 737 700
    Copa Airlines (CM 474)Boeing 737 800
  • Copa Airlines (CM 299)
    • -
    • -
    • -
    • T
    • -
    • -
    • S
  • 14:40 SDQ
    05:54 SCL
    14Hrs, 14m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 14:40 - SCL 05:54 14h 14m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 14:40
    PTYPanama City Tocumen International Airport 21:31
  • PTYPanama City Tocumen International Airport 16:17
    SCLSantiago Arturo Merino Benitez Airport 05:54
  • 14h 14m (5h 14m)
  • 1 Stop PTY · Panama City 5h 14m
  • Copa Airlines (CM 299)Boeing 737 800
    Copa Airlines (CM 277)Boeing 737 Max 9 Passenger
  • Copa Airlines (CM 299)
    • M
    • T
    • W
    • -
    • F
    • S
    • -
  • 17:08 SDQ
    09:00 SCL
    14Hrs, 52m 1 Stop (MIA)
  • SDQSanto Domingo Las Americas Airport 17:08 - SCL 09:00 14h 52m 1 Stop (MIA) Miami
  • SDQSanto Domingo Las Americas Airport 17:08
    MIAMiami International Airport 22:45
  • MIAMiami International Airport 18:38
    SCLSantiago Arturo Merino Benitez Airport 09:00
  • 14h 52m (4h 07m)
  • 1 Stop MIA · Miami 4h 07m
  • American Airlines (AA 1154)Boeing 737 800
    American Airlines (AA 957)Boeing 777 200
  • American Airlines (AA 1154)
    • -
    • T
    • W
    • T
    • F
    • S
    • S
  • 17:15 SDQ
    08:55 SCL
    14Hrs, 40m 1 Stop (MIA)
  • SDQSanto Domingo Las Americas Airport 17:15 - SCL 08:55 14h 40m 1 Stop (MIA) Miami
  • SDQSanto Domingo Las Americas Airport 17:15
    MIAMiami International Airport 22:45
  • MIAMiami International Airport 18:40
    SCLSantiago Arturo Merino Benitez Airport 08:55
  • 14h 40m (4h 05m)
  • 1 Stop MIA · Miami 4h 05m
  • American Airlines (AA 1154)Boeing 737 Max 8 Passenger
    American Airlines (AA 957)Boeing 777 200
  • American Airlines (AA 1154)
    • M
    • -
    • -
    • -
    • -
    • -
    • -
  • 18:15 SDQ
    05:25 SCL
    10Hrs, 10m 1 Stop (BOG)
  • SDQSanto Domingo Las Americas Airport 18:15 - SCL 05:25 10h 10m 1 Stop (BOG)
  • SDQSanto Domingo Las Americas Airport 18:15
    BOGBogota Airport 21:30
  • BOGBogota Airport 19:50
    SCLSantiago Arturo Merino Benitez Airport 05:25
  • 10h 10m (1h 40m)
  • 1 Stop BOG · 1h 40m
  • Avianca (AV 251)Airbus
    Avianca (AV 97)Airbus A320 Neo
  • Avianca (AV 251)
    • -
    • T
    • -
    • T
    • -
    • S
    • -
  • 18:15 SDQ
    05:10 SCL
    9Hrs, 55m 1 Stop (BOG)
  • SDQSanto Domingo Las Americas Airport 18:15 - SCL 05:10 9h 55m 1 Stop (BOG)
  • SDQSanto Domingo Las Americas Airport 18:15
    BOGBogota Airport 21:30
  • BOGBogota Airport 19:50
    SCLSantiago Arturo Merino Benitez Airport 05:10
  • 9h 55m (1h 40m)
  • 1 Stop BOG · 1h 40m
  • Avianca (AV 251)Airbus
    Avianca (AV 97)Airbus A320 Neo
  • Avianca (AV 251)
    • -
    • -
    • -
    • -
    • -
    • -
    • S
  • 18:15 SDQ
    05:10 SCL
    9Hrs, 55m 1 Stop (BOG)
  • SDQSanto Domingo Las Americas Airport 18:15 - SCL 05:10 9h 55m 1 Stop (BOG)
  • SDQSanto Domingo Las Americas Airport 18:15
    BOGBogota Airport 21:30
  • BOGBogota Airport 19:50
    SCLSantiago Arturo Merino Benitez Airport 05:10
  • 9h 55m (1h 40m)
  • 1 Stop BOG · 1h 40m
  • Avianca (AV 251)Airbus
    Avianca (AV 97)Boeing 787 8
  • Avianca (AV 251)
    • -
    • -
    • W
    • -
    • F
    • -
    • -
  • 18:25 SDQ
    09:00 SCL
    13Hrs, 35m 1 Stop (MIA)
  • SDQSanto Domingo Las Americas Airport 18:25 - SCL 09:00 13h 35m 1 Stop (MIA) Miami
  • SDQSanto Domingo Las Americas Airport 18:25
    MIAMiami International Airport 22:45
  • MIAMiami International Airport 19:55
    SCLSantiago Arturo Merino Benitez Airport 09:00
  • 13h 35m (2h 50m)
  • 1 Stop MIA · Miami 2h 50m
  • American Airlines (AA 2171)Boeing 737 800
    American Airlines (AA 957)Boeing 777 200
  • American Airlines (AA 2171)
    • -
    • -
    • -
    • T
    • F
    • S
    • S
  • 18:38 SDQ
    05:54 SCL
    10Hrs, 16m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 18:38 - SCL 05:54 10h 16m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 18:38
    PTYPanama City Tocumen International Airport 21:31
  • PTYPanama City Tocumen International Airport 20:15
    SCLSantiago Arturo Merino Benitez Airport 05:54
  • 10h 16m (1h 16m)
  • 1 Stop PTY · Panama City 1h 16m
  • Copa Airlines (CM 464)Boeing 737 700
    Copa Airlines (CM 277)Boeing 737 Max 9 Passenger
  • Copa Airlines (CM 464)
    • M
    • -
    • -
    • -
    • -
    • -
    • -
  • 18:38 SDQ
    05:54 SCL
    10Hrs, 16m 1 Stop (PTY)
  • SDQSanto Domingo Las Americas Airport 18:38 - SCL 05:54 10h 16m 1 Stop (PTY) Panama City
  • SDQSanto Domingo Las Americas Airport 18:38
    PTYPanama City Tocumen International Airport 21:31
  • PTYPanama City Tocumen International Airport 20:15
    SCLSantiago Arturo Merino Benitez Airport 05:54
  • 10h 16m (1h 16m)
  • 1 Stop PTY · Panama City 1h 16m
  • Copa Airlines (CM 464)Boeing 737 800
    Copa Airlines (CM 277)Boeing 737 Max 9 Passenger
  • Copa Airlines (CM 464)
    • -
    • T
    • W
    • T
    • -
    • S
    • S
No Schedules Sorry, there are no schedules matching your filters. Try removing one. reset
What’s the most popular airline flying from Santo Domingo to Santiago?

The most popular airline flying from Santo Domingo to Santiago is Copa Airlines. Find the latest flight deals on Wego.

How far is Santiago from Santo Domingo?

The flight distance between Santo Domingo and Santiago is 5775km. Check all available flights on Wego.

When is the earliest and latest flight of the day?

The earliest flight of the day departs at 06:16. The last flight of the day departs at 06:16. See the full list of flight times on Wego.